Zufran .. How to use it in the treatment of vomiting and avoid complications
What is Zofran?
Basic information about the medicine:
Pharmaceutical category: Antihypertensives
Business name: Zofran Zofran
Scientific name and active ingredient: Ondansetron
Available dosage form: tablets, injections, soluble tablets.
Other types contain the same active ingredient in the market: Zimtron.
Zofran contains an antidote, a subtype of serotonin. It is not possible to know how an undancitron prevents the vomiting, but studies indicate that it closes the serotonin receptors in the digestive tract as well as the brain, thus disrupting the transmission of the nerve signal that conveys the feeling of nausea and desire to vomit and prevents it from reaching the center of vomiting in the brain. About chemotherapy or cancer treatment.
Indications:
Due to its high efficacy as an anti-serotonin, Zofran is used to treat the following conditions:
Nausea and vomiting associated with or following chemotherapy for cancer.
Nausea and vomiting associated with or following radiation therapy for cancer.
Nausea and vomiting that follows surgery.
Doses and how to use
1 - It is very important that this medicine is used only under the supervision and follow-up medical accurate and only if the patient's condition called for health.
2. Soluble tablets should be placed on the tongue and left to melt slowly and not chewed.
3-Polat injection can be used in the muscle or vein.
4 - coated tablets are taken with a glass of water before eating half an hour or before the date of radiation doses or chemical, and before operations.
Doses for adults are as follows:
Treatment of vomiting and severe nausea after chemotherapy: 24 mg before eating half an hour once a day.
Treatment of vomiting and moderate nausea: 8 mg / twice daily before eating half an hour.
Treatment of vomiting and severe nausea after radiotherapy: 8 mg dose 3 times daily.
Treatment of vomiting and moderate-intensity nausea after radiotherapy: 8 mg twice a day.
Treatment of vomiting and nausea after surgery: 16 mg dose before the operation in an hour.
Doses for children are as follows:
Children or adolescents 40 kg: 0,1 / kg before surgery.
Children 40 kg: 4 mg before operations.
Children 4 to 11 years old and undergoing chemotherapy: 4 mg / 3 times daily; children> 11 years: 8 mg / 2 times daily.
Usage caveats
Taking caution when using Zofran with the following conditions:
Hepatic insufficiency.
Intestinal obstruction cases.
Children under the age of 4 years.
Pulse arrhythmias and rapid pulses.
People who use a pacemaker.
People with electrolyte disorder in the blood, especially magnesium and potassium.
People who have already had tonsillectomy or tonsils.
Contraindications
Zofran is a relatively safe drug, but it is not used in the following cases:
Hypersensitivity to the active ingredient or any of the components of the medicine.
Sensitivity of lactose.
Use with pregnancy and breastfeeding
Use during pregnancy depends on the extent of the desired benefits against the expected risks. For Zofran, the active ingredient "Ondansetron" is classified as a Class B drug according to the FDA classification. Despite this safe classification of Nsabia, a number of studies and research have recently emerged concerning Zofran's association with congenital problems and defects in the fetus.
In the case of breastfeeding, there is not enough studies on Zofran and whether the active ingredient in the breast milk is released to the mother of the mother or not, and can not determine the type of damage resulting from this and therefore should not be used Zofran during the period of breastfeeding only if the doctor sees it .
Possible side effects:
Like any other drug, the use of Zofran may cause a range of side effects that vary from person to person, some of which may appear or all or nothing at all to users. Of these symptoms:
Common side effects:
And include symptoms of simple and usual may be the most constipation, but most do not cause concern, and some of them:
a headache.
Constipation.
Less common side effects:
These symptoms occur in rare cases and some may require consultation with the doctor, including:
Involuntary movements.
Spasmodic seizures.
Arrhythmia.
Slow heartbeat.
pain in chest.
Reduction of Blood pressure.
fainting.
Liver dysfunction.
Dizziness and general depression especially with intravenous injection.
Change in heartbeat and in particular ECG.
Severe allergic reactions such as swelling, redness, swelling of the face, lips and tongue.
Stress and feeling tired.
Idle and sleepy.
In rare cases, the so-called serotonin syndrome is caused by the high concentration of serotonin in the body, and this condition requires discontinuation of treatment after the doctor to treat the symptoms associated with it.